Publikationen
Publikationen aus unserer Forschung im Überblick
Publikationen zur Personalisierten Medizin ansehen
3757376
3ITDHJV5
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https://www.molit.eu/wp-content/plugins/zotpress/
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Larribère, L., Gordejeva, J., Kuhnhenn, L., Kurscheidt, M., Pobiruchin, M., Vladimirova, D., Martin, M., Roser, M., Schramm, W., Martens, U. M., & Eigenbrod, T. (2021). Assessment of SARS-CoV-2 Infection among Healthcare Workers of a German COVID-19 Treatment Center. International Journal of Environmental Research and Public Health, 18(13), 7057. https://doi.org/10.3390/ijerph18137057
Latzer, P., Zelba, H., Battke, F., Reinhardt, A., Shao, B., Bartsch, O., Rabsteyn, A., Harter, J., Schulze, M., Okech, T., Golf, A., Kyzirakos-Feger, C., Kayser, S., Pieper, N., Feldhahn, M., Wünsche, J., Seitz, C., Hadaschik, D., Garbe, C., … Biskup, S. (2024). A real-world observation of patients with glioblastoma treated with a personalized peptide vaccine. Nature Communications, 15(1), 6870. https://doi.org/10.1038/s41467-024-51315-8
Vladimirova, D., Bochum, S., Weiß, M., & Martens, U. M. (2022). Molekulares Profiling für Diagnose und Therapieentscheidung beim CUP Syndrom: Fallbericht aus einer monozentrischen Studie. Oncology Research and Treatment, 45(suppl 2), 5–346. https://doi.org/https://doi.org/10.1159/000526456
Vladimirova, D., Mbonu, P., Umapathy, M., Kothapalli, P., Otmacic, G., Akkad, J., Weyersberg, S., Martens, U. M., & Jechlinger, M. (2022). Etablierung einer Gewebe-Pipeline für multidimensionale Analysen beim metastasierten kolorektalen Karzinom. Oncology Research and Treatment, 45(suppl 2), 5–346. https://doi.org/https://doi.org/10.1159/000526456
Bochum, S., Ulmer, M., Rohlfing, S., Schmohl, J., Löffler, H., Knott, M., Weßendorf, S., Hänle, C., Greiner, J., Denzlinger, C., Illerhaus, G., Ganten, T., Sipos, B., Biskup, S., Vladimirova, D., Sigle, S., Zsebedits, D., Fegeler, C., & Martens, U. M. (2022). ZvPM - Implementierung eines IT-gestützten überregionalen Molekularen Tumorboards (MTB). Oncology Research and Treatment, 45(suppl 2), 5–346. https://doi.org/https://doi.org/10.1159/000526456
Vladimirova, D., Bochum, S., Larribere, L., Kocher, S., Gallo, N., Sigle, S., Beutter, C. N. L., Biskup, S., Fegeler, C., & Martens, U. M. (2020). GASTRY: eine monozentrische Registerstudie zur Erfassung klinischer, molekularer und Lebensqualitätsparameter bei Patienten mit gastrointestinalen Tumoren / GASTRY: a monocentric registry study to record clinical, molecular and quality of life parameters in patients with gastrointestinal tumors. DGHO-Jahrestagung, Supplement Im Oncology Research and Treatment 2020. DGHO, Berlin. https://www.professionalabstracts.com/dgho2020/programme-dgho2020.pdf
Martens, U. M., Bochum, S., Mergel, F., Schiliro, A., Gallo, N., Pereira, P., Sipos, B., & Vladimirova, D. (2020). Rasches Therapieansprechen auf Larotrectinib bei mCRC-Patienten mit neuartiger onkogener NTRK-TP53 Fusion / Rapid clinical response to Larotrectinib in a mCRC patient with a novel oncogenic NTRK1-TP53 fusion. DGHO-Jahrestagung, Supplement Im Oncology Research and Treatment 2020, 133. https://www.professionalabstracts.com/dgho2020/programme-dgho2020.pdf
Bochum, S., Schall, L., Martens, U. M., Fegeler, C., & Pobiruchin, M. (2020). Pooling Clinical Cancer Registry Data with Public Genomic Datasets. Already an option to enhance real world evidence in precision oncology? DGHO-Jahrestagung, Supplement Im Oncology Research and Treatment 2020. DGHO. https://www.professionalabstracts.com/dgho2020/programme-dgho2020.pdf
Schall, L., Bochum, S., & Pobiruchin, M. (2020). Merging Genomics Public Datasets with Clinical Cancer Registry Data – Lessons Learned. GMDS.
Bochum, S. (n.d.). Platin-basierte Chemotherapeutika verlängern das Überleben von Pankreaskarzinom-Patienten mit einer Keimbahn-Mutation in BRCAness-Genen. Oncology Research and Treatment. https://doi.org/10.1159/000502425
Bochum, S., Vladimirova, D., Schiliro, A., Akkad, J., Autschbach, F., Finkeisen, D., Keil, A., Biskup, S., Fegeler, C., & Martens, U. M. (2019). Prolonged overall survival of pancreatic cancer patients with BRCAness germline mutations treated with DNA-damaging agents. Oncology Research and Treatment, 36. https://doi.org/10.1159/000502425
Bochum, S., & Martens, U. M. (2019). Keimbahnmutationen können über Therapieerfolg entscheiden. JATROS Hämatologie & Onkologie. https://www.universimed.com/at/article/onkologie/keimbahnmutationen-koennen-ueber-therapieerfolg-entscheiden-2122385
Berger, S., Bochum, S., Finkeisen, D., Schilliro, A., Autschbach, F., Bischof, M., Hagmueller, E., Pereira, P. L., Weickert, U., Sipos, B., Biskup, S., & Martens, U. M. (2018). Sustainable Response of a Patient With Metastasized Pancreatic Cancer and a Hypermutational Phenotype to Immunotherapy. New Therapeutic Concept for a Rare Subtype? JCO Precision Oncology, 2, 1–6. https://doi.org/10.1200/PO.18.00005
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Janda, E., Lehmann, K., Killisch, I., Jechlinger, M., Herzig, M., Downward, J., Beug, H., & Grünert, S. (2002). Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways. The Journal of Cell Biology, 156(2), 299–313. https://doi.org/10.1083/jcb.200109037
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Jechlinger, M., Grunert, S., Tamir, I. H., Janda, E., Lüdemann, S., Waerner, T., Seither, P., Weith, A., Beug, H., & Kraut, N. (2003). Expression profiling of epithelial plasticity in tumor progression. Oncogene, 22(46), 7155–7169. https://doi.org/10.1038/sj.onc.1206887
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Jechlinger, M., Sommer, A., Moriggl, R., Seither, P., Kraut, N., Capodiecci, P., Donovan, M., Cordon-Cardo, C., Beug, H., & Grünert, S. (2006). Autocrine PDGFR signaling promotes mammary cancer metastasis. The Journal of Clinical Investigation, 116(6), 1561–1570. https://doi.org/10.1172/JCI24652
Waerner, T., Alacakaptan, M., Tamir, I., Oberauer, R., Gal, A., Brabletz, T., Schreiber, M., Jechlinger, M., & Beug, H. (2006). ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells. Cancer Cell, 10(3), 227–239. https://doi.org/10.1016/j.ccr.2006.07.020
Siwko, S. K., Bu, W., Gutierrez, C., Lewis, B., Jechlinger, M., Schaffhausen, B., & Li, Y. (2008). Lentivirus-mediated oncogene introduction into mammary cells in vivo induces tumors. Neoplasia (New York, N.Y.), 10(7), 653–662, 1 p following 662. https://doi.org/10.1593/neo.08266
Podsypanina, K., Du, Y.-C. N., Jechlinger, M., Beverly, L. J., Hambardzumyan, D., & Varmus, H. (2008). Seeding and propagation of untransformed mouse mammary cells in the lung. Science (New York, N.Y.), 321(5897), 1841–1844. https://doi.org/10.1126/science.1161621
Jechlinger, M., Podsypanina, K., & Varmus, H. (2009). Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction. Genes & Development, 23(14), 1677–1688. https://doi.org/10.1101/gad.1801809
Rhim, A. D., Jechlinger, M., & Rustgi, A. K. (2015). Culturing mouse tumor cells. Cold Spring Harbor Protocols, 2015(6), 505–507. https://doi.org/10.1101/pdb.top069989
Rowald, K., Mantovan, M., Passos, J., Buccitelli, C., Mardin, B. R., Korbel, J. O., Jechlinger, M., & Sotillo, R. (2016). Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth. Cell Reports, 15(12), 2679–2691. https://doi.org/10.1016/j.celrep.2016.05.048
Koehler, C., Sauter, P. F., Wawryszyn, M., Girona, G. E., Gupta, K., Landry, J. J. M., Fritz, M. H.-Y., Radic, K., Hoffmann, J.-E., Chen, Z. A., Zou, J., Tan, P. S., Galik, B., Junttila, S., Stolt-Bergner, P., Pruneri, G., Gyenesei, A., Schultz, C., Biskup, M. B., … Lemke, E. A. (2016). Genetic code expansion for multiprotein complex engineering. Nature Methods, 13(12), 997–1000. https://doi.org/10.1038/nmeth.4032
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Jechlinger, M., Kendrick, H., Smalley, M., & Vivanco, M. dM. (2017). See One, Do One, Teach One: A Practical Course on Methods in Mammary Gland Biology. Journal of Mammary Gland Biology and Neoplasia, 22(4), 215–219. https://doi.org/10.1007/s10911-017-9387-6
Alladin, A., Chaible, L., Garcia Del Valle, L., Sabine, R., Loeschinger, M., Wachsmuth, M., Hériché, J.-K., Tischer, C., & Jechlinger, M. (2020). Tracking cells in epithelial acini by light sheet microscopy reveals proximity effects in breast cancer initiation. ELife, 9, e54066. https://doi.org/10.7554/eLife.54066
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D’Imprima, E., Garcia Montero, M., Gawrzak, S., Ronchi, P., Zagoriy, I., Schwab, Y., Jechlinger, M., & Mahamid, J. (2023). Light and electron microscopy continuum-resolution imaging of 3D cell cultures. Developmental Cell, 58(7), 616-632.e6. https://doi.org/10.1016/j.devcel.2023.03.001
van Amerongen, R., Bentires-Alj, M., van Boxtel, A. L., Clarke, R. B., Fre, S., Suarez, E. G., Iggo, R., Jechlinger, M., Jonkers, J., Mikkola, M. L., Koledova, Z. S., Sørlie, T., & Vivanco, M. dM. (2023). Imagine beyond: recent breakthroughs and next challenges in mammary gland biology and breast cancer research. Journal of Mammary Gland Biology and Neoplasia, 28(1), 17. https://doi.org/10.1007/s10911-023-09544-y
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Starostecka, M., Jeong, H., Hasenfeld, P., Benito-Garagorri, E., Christiansen, T., Stober Brasseur, C., Gomes Queiroz, M., Garcia Montero, M., Jechlinger, M., & Korbel, J. O. (2025). Structural variant and nucleosome occupancy dynamics postchemotherapy in a HER2+ breast cancer organoid model. Proceedings of the National Academy of Sciences of the United States of America, 122(9), e2415475122. https://doi.org/10.1073/pnas.2415475122
Radic Shechter, K., Kafkia, E., Zirngibl, K., Gawrzak, S., Alladin, A., Machado, D., Lüchtenborg, C., Sévin, D. C., Brügger, B., Patil, K. R., & Jechlinger, M. (2021). Metabolic memory underlying minimal residual disease in breast cancer. Molecular Systems Biology, 17(10). https://doi.org/10.15252/msb.202010141
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Ozturk, M. S., Montero, M. G., Wang, L., Chaible, L. M., Jechlinger, M., & Prevedel, R. (2021). Intravital mesoscopic fluorescence molecular tomography allows non-invasive in vivo monitoring and quantification of breast cancer growth dynamics. Communications Biology, 4(1), 556. https://doi.org/10.1038/s42003-021-02063-8
Rubio, T., Weyershaeuser, J., Montero, M. G., Hoffmann, A., Lujan, P., Jechlinger, M., Sotillo, R., & Köhn, M. (2021). The phosphatase PRL-3 affects intestinal homeostasis by altering the crypt cell composition. Journal of Molecular Medicine, 99(10), 1413–1426. https://doi.org/10.1007/s00109-021-02097-9
Ronchi, P., Mizzon, G., Machado, P., D’Imprima, E., Best, B. T., Cassella, L., Schnorrenberg, S., Montero, M. G., Jechlinger, M., Ephrussi, A., Leptin, M., Mahamid, J., & Schwab, Y. (2021). High-precision targeting workflow for volume electron microscopy. Journal of Cell Biology, 220(9), e202104069. https://doi.org/10.1083/jcb.202104069
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Lingg, M., Beutter, C., Sigle, S., Zsebedits, D., & Fegeler, C. (2023). Challenge of Detecting Personal Deviations and Trends in Sensor Based Activity Data. In R. Röhrig, N. Grabe, M. Haag, U. Hübner, U. Sax, C. Oliver Schmidt, M. Sedlmayr, & A. Zapf (Eds.), Studies in Health Technology and Informatics. IOS Press. https://doi.org/10.3233/SHTI230711
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Beutter, C. N. L., Vladimirova, D., Martens, U. M., & Fegeler, C. (2023). Clinical use of quality of life data for treatment and survivorship in oncology. Journal of Clinical Oncology, 41(16_suppl), e24044–e24044. https://doi.org/10.1200/JCO.2023.41.16_suppl.e24044
Sigle, S., Werner, P., & Fegeler, C. (2022). Implementation of an Interoperable Order-Entry Process for Virtual Molecular Tumorboards. Oncology Research and Treatment, 45(suppl 2), 5–346. https://doi.org/https://doi.org/10.1159/000526456
Beutter, C. N. L., Imeraj, E., Martens, U. M., & Fegeler, C. (2022). Concept of a data driven system to accomplish a longitudinal survey of quality of life in oncology. https://doi.org/10.3205/22GMDS030
Mathes, G., Sigle, S., & Fegeler, C. (2022). Design and implementation of a decision support system for eligibility of patients within oncologic precision trials. https://doi.org/10.3205/22GMDS003
Beutter, C. N. L., Martens, U. M., & Fegeler, C. (2022). From patient generated data to precision medicine: An example of a patient-centered application in oncology. Journal of Clinical Oncology, 40(16_suppl), e13559–e13559. https://doi.org/10.1200/JCO.2022.40.16_suppl.e13559
Sigle, S., Kaufmes, K., Werner, P., Bochum, S., Martens, U., & Fegeler, C. (2021). Variant Browser: A comprehensive information retrieval tool for molecular genetics in a precision oncology setting. Oncology Research and Treatment, 44(2), 96–97. https://doi.org/10.1159/000518417
Sigle, S., Kaufmes, K., Werner, P., Bochum, S., Martens, U., & Fegeler, C. (2021). Introducing Variant Browser – a Meta Search Plattform for Genetic Variants. DocAbstr. 48. https://doi.org/10.3205/21gmds054
Sigle, S., Bochum, S., Werner, P., Walter, D., Martens, U. M., & Fegeler, C. (2020). Taming Data Sources to enable interoperable Clinical Decision Support for Virtual Molecular Tumor Boards. DGHO-Jahrestagung, Supplement Im Oncology Research and Treatment 2020, 69. https://doi.org/10.1159/isbn.978-3-318-06715-6
Sigle, S. (2020, November 17). Establishing Clinical Decision Support for Virtual Molecular Tumor Boards. FHIR Dev Days 2020. https://www.devdays.com/wp-content/uploads/2020/12/zibbw_201117_StefanSigle_Establishing_Clinical_Decision_Support_for_Virtual_Molecular_Tumor_Boards.pdf
Sigle, S., Werner, P., Bochum, S., Finkeisen, D., Martens, U. M., & Fegeler, C. (2020). Interoperable Knowledge- and Decision Support Components in Virtual Molecular Tumor Boards. GMDS.
Molekularpathologie on FHIR: Der Clinical Genomics Implementation Guide. (2020). DMEA – SParks.
Keil, A., Sigle, S., Bochum, S., & Fegeler, C. (2019). Drowning in Information: The lack of integrating Knowledge Databases. Oncology Research and Treatment, 61. https://doi.org/10.1159/000502425
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